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000719lg Enteric coated erythomycin

Enteric-coated erythromycin capsule from Abbott Lab.

HistoryEdit

The major antibiotic was launched commercially in 1952 under the brand name Ilosone (after the Philippine region of Iloilo where it was originally collected). Erythromycin was formerly also called Ilotycin. It got the U.S. patent number  2,653,899 in 1953.

  1. Formula- C37H67NO13
  2. Molar mass- 733.94 g·mol−1
  3. Biological half-life- 1.5 hours

It is on the World Health Organization's List of Essential Medicines, the most effective and safe medicines needed in a health system.

Target illnessEdit

Erythromycin can be used to treat bacteria responsible for causing infections of the skin and upper respiratory tract, including Streptococcus, Staphylococcus, Haemophilus and Corynebacterium genera.

Side effectsEdit

Gastrointestinal disturbances, such as diarrhea, nausea, abdominal pain, and vomiting, are very common because erythromycin is a motilin agonist.

More serious side effects include arrhythmia with prolonged QT intervals including torsades de pointes, and reversible deafness. Allergic reactions range from urticaria to anaphylaxis. Cholestasis, Stevens–Johnson syndrome, and toxic epidermal necrolysis are some other rare side effects that may occur.

Erythromycin related compoundsEdit

  1. Azithromycin
  2. Carbomycin
  3. Cethromycin
  4. Clarithromycin
  5. Dirithromycin
  6. Erythromycin/tretinoin
  7. Mitemcinal
  8. Oleandomycin
  9. Roxithromycin
  10. Spiramycin
  11. Telithromycin
  12. Tylosin

CostEdit

It is available as a generic medication and is inexpensive. The wholesale price is between 0.03 and 0.06 USD per pill. In the United States in 2014 the price increased to seven dollars per tablet. The wholesale price in the developing world is also between 0.03 and 0.06 USD per tablet.

Also seeEdit

SourcesEdit

  1. http://www.ebi.ac.uk/pdbe-srv/PDBeXplore/ligand/?ligand=ERY
  2. http://v3.espacenet.com/origdoc?DB=EPODOC&IDX=US2653899&F=0&QPN=US2653899
  3. http://www.rxlist.com/erythromycin-ethylsuccinate-drug.htm
  4. http://mshpriceguide.org/en/single-drug-information/?DMFId=311&searchYear=2014
  5. https://books.google.ca/books?id=XUuFPxvfWgAC&pg=PA52#v=onepage&q&f=false
  6. https://www.tga.gov.au/prescribing-medicines-pregnancy-database#.U1Yw8Bc3tqw
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722580/
  8. https://books.google.ca/books?id=XUuFPxvfWgAC&pg=PA52#v=onepage&q&f=false
  9. https://www.wikiwand.com/en/Erythromycin
  10. https://en.wikipedia.org/wiki/Erythromycin?oldformat=true
  11. https://www.wikiwand.com/en/Erythromycin
  12. ttps://upload.wikimedia.org/wikipedia/commons/8/88/000719lg_Enteric_coated_erythomycin.jpg
  13. https://books.google.ca/books?id=XUuFPxvfWgAC&pg=PA52#v=onepage&q&f=false
  14. https://commons.wikimedia.org/wiki/File:000719lg_Enteric_coated_erythomycin.jpg
  15. https://www.tga.gov.au/prescribing-medicines-pregnancy-database#.U1Yw8Bc3tqw
  16. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722580/
  17. http://erc.msh.org/dmpguide/resultsdetail.cfm?language=english&code=ERY250T&s_year=2014&year=2014&str=250%20mg&desc=Erythromycin&pack=new&frm=TAB-CAP&rte=PO&class_code2=06%2E2%2E2%2E&supplement=&class_name=%2806%2E2%2E2%2E%29Other%20antibacterials%3Cbr%3E
  18. http://online.lexi.com/lco/action/doc/retrieve/docid/74/304361
  19. https://books.google.ca/books?id=zJay-fZCFGgC&pg=PA72#v=onepage&q&f=false
  20. http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/1831759#f_pregnancy-and-lactation
  21. http://philadelphia.cbslocal.com/2014/09/26/health-generic-drugs-prices-increasing/
  22. https://en.wikipedia.org/wiki/Erythromycin?oldformat=true
  23. https://books.google.ca/books?id=zJay-fZCFGgC&pg=PA72#v=onepage&q&f=false
  24. http://erc.msh.org/dmpguide/resultsdetail.cfm?language=english&code=ERY250T&s_year=2014&year=2014&str=250%20mg&desc=Erythromycin&pack=new&frm=TAB-CAP&rte=PO&class_code2=06%2E2%2E2%2E&supplement=&class_name=%2806%2E2%2E2%2E%29Other%20antibacterials%3Cbr%3E
  25. http://philadelphia.cbslocal.com/2014/09/26/health-generic-drugs-prices-increasing/
  26. https://www.drugs.com/monograph/erythromycin.html
  27. https://books.google.ca/books?id=XUuFPxvfWgAC&pg=PA52#v=onepage&q&f=false
  28. https://www.tga.gov.au/prescribing-medicines-pregnancy-database#.U1Yw8Bc3tqw
  29. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722580/