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Erythromycin

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000719lg Enteric coated erythomycin

Enteric-coated erythromycin capsule from Abbott Lab.

HistoryEdit

The major antibiotic was launched commercially in 1952 under the brand name Ilosone (after the Philippine region of Iloilo where it was originally collected). Erythromycin was formerly also called Ilotycin. It got the U.S. patent number  2,653,899 in 1953.

  1. Formula- C37H67NO13
  2. Molar mass- 733.94 g·mol−1
  3. Biological half-life- 1.5 hours

Target illnessEdit

Erythromycin can be used to treat bacteria responsible for causing infections of the skin and upper respiratory tract, including Streptococcus, Staphylococcus, Haemophilus and Corynebacterium genera.

Side effectsEdit

Gastrointestinal disturbances, such as diarrhea, nausea, abdominal pain, and vomiting, are very common because erythromycin is a motilin agonist.

More serious side effects include arrhythmia with prolonged QT intervals including torsades de pointes, and reversible deafness. Allergic reactions range from urticaria to anaphylaxis. Cholestasis, Stevens–Johnson syndrome, and toxic epidermal necrolysis are some other rare side effects that may occur.

Erythromycin related compoundsEdit

  1. Azithromycin
  2. Carbomycin
  3. Cethromycin
  4. Clarithromycin
  5. Dirithromycin
  6. Mitemcinal
  7. Oleandomycin
  8. Roxithromycin
  9. Spiramycin
  10. Telithromycin
  11. Tylosin

CostEdit

It is available as a generic medication and is inexpensive. The wholesale price is between 0.03 and 0.06 USD per pill. In the United States in 2014 the price increased to seven dollars per tablet.

Also seeEdit

SourcesEdit

  1. https://books.google.ca/books?id=XUuFPxvfWgAC&pg=PA52#v=onepage&q&f=false
  2. https://www.tga.gov.au/prescribing-medicines-pregnancy-database#.U1Yw8Bc3tqw
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722580/
  4. https://books.google.ca/books?id=XUuFPxvfWgAC&pg=PA52#v=onepage&q&f=false
  5. https://www.wikiwand.com/en/Erythromycin
  6. https://en.wikipedia.org/wiki/Erythromycin?oldformat=true
  7. https://www.wikiwand.com/en/Erythromycin
  8. ttps://upload.wikimedia.org/wikipedia/commons/8/88/000719lg_Enteric_coated_erythomycin.jpg
  9. https://books.google.ca/books?id=XUuFPxvfWgAC&pg=PA52#v=onepage&q&f=false
  10. https://commons.wikimedia.org/wiki/File:000719lg_Enteric_coated_erythomycin.jpg
  11. https://www.tga.gov.au/prescribing-medicines-pregnancy-database#.U1Yw8Bc3tqw
  12. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722580/
  13. http://erc.msh.org/dmpguide/resultsdetail.cfm?language=english&code=ERY250T&s_year=2014&year=2014&str=250%20mg&desc=Erythromycin&pack=new&frm=TAB-CAP&rte=PO&class_code2=06%2E2%2E2%2E&supplement=&class_name=%2806%2E2%2E2%2E%29Other%20antibacterials%3Cbr%3E
  14. http://online.lexi.com/lco/action/doc/retrieve/docid/74/304361
  15. https://books.google.ca/books?id=zJay-fZCFGgC&pg=PA72#v=onepage&q&f=false
  16. http://online.lexi.com/lco/action/doc/retrieve/docid/patch_f/1831759#f_pregnancy-and-lactation
  17. http://philadelphia.cbslocal.com/2014/09/26/health-generic-drugs-prices-increasing/
  18. https://en.wikipedia.org/wiki/Erythromycin?oldformat=true
  19. https://books.google.ca/books?id=zJay-fZCFGgC&pg=PA72#v=onepage&q&f=false
  20. http://erc.msh.org/dmpguide/resultsdetail.cfm?language=english&code=ERY250T&s_year=2014&year=2014&str=250%20mg&desc=Erythromycin&pack=new&frm=TAB-CAP&rte=PO&class_code2=06%2E2%2E2%2E&supplement=&class_name=%2806%2E2%2E2%2E%29Other%20antibacterials%3Cbr%3E
  21. http://philadelphia.cbslocal.com/2014/09/26/health-generic-drugs-prices-increasing/
  22. https://www.drugs.com/monograph/erythromycin.html
  23. https://books.google.ca/books?id=XUuFPxvfWgAC&pg=PA52#v=onepage&q&f=false
  24. https://www.tga.gov.au/prescribing-medicines-pregnancy-database#.U1Yw8Bc3tqw
  25. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722580/

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